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首页> 外文OA文献 >Vitamin D3 correlates inversely with systemic dendritic cell numbers and bone erosion in chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis
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Vitamin D3 correlates inversely with systemic dendritic cell numbers and bone erosion in chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis

机译：维生素D3与慢性鼻-鼻窦炎伴鼻息肉和过敏性真菌性鼻-鼻窦炎的全身树突状细胞数量和骨侵蚀呈负相关

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Vitamin D3 (VD3) is a steroid hormone that regulates bone health and numerous aspects of immune function and may play a role in respiratory health. We hypothesized that T helper type 2 (Th2) disorders, chronic rhinosinusitis with nasal polyps (CRSwNP) and allergic fungal rhinosinusitis (AFRS) would have VD3 deficiencies, resulting in increased mature dendritic cells (DCs) and bone erosion. We conducted a retrospective study examining VD3 levels in patients with AFRS (n = 14), CRSwNP (n = 9), chronic rhinosinusitis without nasal polyps (CRSsNP) (n = 20) and cerebrospinal fluid leak repair (non-diseased controls) (n = 14) at time of surgery. Circulating immune cell levels were determined by immunostaining and flow cytometric analysis. Plasma VD3 and immune regulatory factors (granulocyte–macrophage colony-stimulating factor and prostaglandin E2) were measured by enzyme-linked immunosorbent assay. It was observed that CRSwNP and AFRS demonstrated increased circulating DCs, while chronic rhinosinusitis without nasal polyps displayed increased circulating macrophages. CRSwNP and AFRS were to found to have insufficient levels of VD3 which correlated inversely with circulating numbers of mature DCs, DC regulatory factors and bone erosion. CRSsNP displayed no change in circulating DC numbers or VD3 status compared to control, but did display increased numbers of circulating macrophages that was independent of VD3 status. Lastly, VD3 deficiency was associated with more severe bone erosion. Taken together, these results suggest support a role for VD3 as a key player in the immunopathology of CRSwNP and AFRS.
机译：维生素D3（VD3）是一种类固醇激素，可调节骨骼健康和免疫功能的许多方面，并可能在呼吸健康中起作用。我们假设T型辅助2型（Th2）疾病，慢性鼻-鼻息肉鼻窦炎（CRSwNP）和过敏性真菌性鼻-鼻窦炎（AFRS）会具有VD3缺陷，导致成熟树突状细胞（DC）增多和骨侵蚀。我们进行了一项回顾性研究，研究了AFRS（n = 14），CRSwNP（n = 9），无鼻息肉的慢性鼻鼻窦炎（CRSsNP）（n = 20）和脑脊液渗漏修复（非疾病对照）患者的VD3水平（ n = 14）。通过免疫染色和流式细胞仪分析确定循环免疫细胞水平。通过酶联免疫吸附法测定血浆VD3和免疫调节因子（粒细胞-巨噬细胞集落刺激因子和前列腺素E2）。观察到CRSwNP和AFRS显示循环DC增加，而没有鼻息肉的慢性鼻-鼻窦炎显示循环巨噬细胞增加。发现CRSwNP和AFRS的VD3水平不足，这与成熟DC的循环数，DC调节因子和骨侵蚀成反比。与对照相比，CRSsNP显示循环DC数目或VD3状态无变化，但显示循环巨噬细胞数量增加，而与VD3状态无关。最后，VD3缺乏与更严重的骨侵蚀有关。综上所述，这些结果表明支持VD3在CRSwNP和AFRS免疫病理学中的关键作用。

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